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February 12.2026
2 Minutes Read

How MFN Pricing May Shape Future Drug Prices in the US and Canada

How MFN Pricing May Shape Future Drug Prices in the US and Canada


The Impact of MFN on US Drug Pricing: An Overview

With rising healthcare costs continuously making headlines, the most favored nation (MFN) pricing model emerges as a promising yet contentious solution to drug pricing disparities. A recent analysis by researchers Pierre Dubois, Ashvin Gandhi, and Shoshana Vasserman provides critical insights into how international reference pricing influences pharmaceutical costs, particularly in the US and Canada.

Understanding the Demand and Supply Models

The researchers utilized sophisticated econometric models, drawing from IQVIA data spanning over a decade to gauge the implications of MFN on drug prices. Their approach involved an in-depth demand model based on the Anatomical Therapeutic and Chemical (ATC) classification which allowed them to assess how competition amongst similar products affects consumer choice. They also employed a supply-side model that leverages Nash bargaining principles, simulating how firms and regulators interact to set prices.

Potential Outcomes of Implementing MFN

Despite theoretical advantages of a system where US prices cannot exceed those in Canada, the study concludes that introducing MFN pricing will minimally affect US expenditures. In contrast, it could lead to significant price hikes in Canada due to how pricing strategies are interlinked within these two markets. This negotiation mechanism suggests that the profits in the larger US market profoundly influence pricing structures and the Canadian market becomes a reference point, thus elevating its prices.

Implications for Concierge Medical Practices

For concierge medical practice owners, understanding MFN's potential design and its ramifications is crucial. The diminished price reductions in the US signify that practitioners may need to navigate new financial landscapes when budgeting for medications. However, the risk of inflated drug prices in Canada could equally temper patient demand, affecting practice revenues in both regions.

Future Outlook: What Can We Expect?

The ramifications of MFN pricing could evolve as the proposed models undergo revisions in response to political and economic pressures. For doctors and medical entrepreneurs, staying informed on these regulatory shifts is vital for strategic practice management. The exploration into more countries as pricing references could change initial findings, but any substantial shifts in US market dynamics would likely remain limited given the vast profitability of this market.

Final Thoughts

As the healthcare sector continues to confront drug pricing challenges, the MFN pricing model is an emerging area warranting close attention. Beyond just compliance, understanding these frameworks can empower practice owners to develop innovative strategies, ensuring their services remain competitive and sustainable. Keeping abreast of such changes will be essential not only for regulatory compliance but also for the overall financial health of concierge practices.


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